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Cold Sore Treatment Comparison - July 2025
| 1 Best Choice  9.9Exceptional | 2  9.8Exceptional | 3 Best Value  9.6Exceptional | 4  9.5Excellent | 5  9.4Excellent | 6  9.3Excellent | 7  9.1Excellent |
| View DealOn Amazon | View DealOn Amazon | View DealOn Amazon | View DealOn Amazon | View DealOn Amazon | View DealOn Amazon | View DealOn Amazon |
ModelAbreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2 | Model Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz | Model Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz | Model Orajel Touch Free Cold Sore Treatment .12oz, Liquid Formula, Provides Immediate & Targeted Pain Relief, Bonus Size, 6 Applicators. | Model Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count | Model TARO Cold Sore/Fever Blister Treatment - Docosanol 10% Cream (0.07 oz - 2 Tube) | Model Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams |
BrandAbreva | Brand Quantum | Brand Campho-Phenique | Brand Orajel | Brand Mederma | Brand TARO | Brand Abreva |
Reviews | Reviews | Reviews | Reviews  | Reviews | Reviews | Reviews |
Features | ||||||
Worth the money 9.1 | Worth the money 9.4 | Worth the money 9.4 | Worth the money 8.6 | Worth the money 8.4 | Worth the money 7.6 | Worth the money 7.4 |
Flavor 8.9 | Flavor 8.9 | Flavor 7.9 | Flavor 9.1 | Flavor 8.6 | Flavor 7.2 | Flavor 7.0 |
Tech Specs | ||||||
product dimensions1.71 x 5.1 x 5.5 inches 1.76 ounces | product dimensions 1 x 3.5 x 4.9 inches 0.16 ounces | product dimensions 0.75 x 3.31 x 4.09 inches 0.23 ounces | product dimensions 4.75 x 3.75 x 1 inches 0.86 ounces | product dimensions 6.1 x 4.3 x 0.8 inches 0.63 ounces | product dimensions - | product dimensions - |
Review | Review | Review | Review | Review | Review - | Review - |
Available On  | Available On | Available On | Available On | Available On | Available On | Available On |
Our Top 3 Picks
Here are the top 3 recommended products with more information to help you find the right product for you
9.8
2Quantum34% OffQuantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz
9.4 worth the money8.9 FlavorWhy we love it
Halves cold sore healing time.
Rapid relief from pain and itching.
Invisible balm for discreet use.
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9.6
3Campho-Phenique52% Off
Campho Phenique Cold Sore and Fever Blister Treatment for Lips, Maximum Strength Provides Instant Relief, Helps Prevent Infection To Promote Healing, Original Gel Formula, 0.23 Oz
9.4 worth the money7.9 FlavorWhy we love it
Instantly relieves pain and itch.
Promotes fast healing of cold sores.
Versatile for various skin irritations.
Cold Sore Treatment Buyer's Guide
Written by Libby JohnsonIntro
When it comes to cold sore treatment, there are a variety of options available to help alleviate the symptoms and prevent further outbreaks. While some treatments are designed to be applied directly to the sore, others are taken orally or applied in a cream or ointment form. Depending on the severity of the outbreak, some treatments may need to be used in conjunction with one another. It is important to understand the different types of treatments available, as well as their individual benefits and drawbacks, in order to choose the best option for your particular needs. In this guide, we will discuss the different types of cold sore treatments and provide a comparison of their features.
Oral Antiviral Medications
Oral antiviral medications are a popular form of cold sore treatment and are available both over the counter and on prescription. These medications work by preventing the virus from replicating and can significantly reduce the length of an outbreak as well as the severity of symptoms. Commonly prescribed antiviral medications include acyclovir, valacyclovir, and famciclovir, although there are other options available. These medications tend to be more effective when taken at the earliest signs of an outbreak, so it is important to act quickly if you suspect that you may be developing a cold sore.
Topical Creams and Ointments
Topical creams and ointments can be applied directly to the affected area as soon as the cold sore begins to develop. These treatments are designed to speed up the healing process and can reduce the severity of the symptoms. Commonly used topical creams and ointments include docosanol, penciclovir, and acyclovir. These treatments should be applied several times a day for the best results and can be purchased over the counter or on prescription.
Home Remedies
In addition to the treatments mentioned above, there are also several home remedies that may be effective in treating cold sores. One of the most popular home remedies is the application of a cold compress or ice pack directly to the affected area. This can help to reduce inflammation and can speed up the healing process. Another popular home remedy is the application of a mixture of equal parts of honey and cinnamon directly to the sore. This mixture has been known to reduce redness and swelling, as well as helping to speed up the healing process.
Prevention
In addition to treating an outbreak, it is also important to take steps to prevent future outbreaks. One of the best ways to prevent cold sores is to practice good hygiene, such as washing your hands often and avoiding sharing personal items, such as lip balms or lipsticks. It is also important to avoid coming into contact with people who have active cold sores, as this can increase the risk of spreading the virus. Wearing sunscreen and avoiding excessive exposure to the sun can also help to prevent outbreaks, as sunburn can trigger a cold sore.
Conclusion
Cold sore treatment is an important part of managing the virus and preventing further outbreaks. The different types of treatments available vary in terms of their effectiveness and the types of symptoms they are designed to treat. Oral antiviral medications, topical creams and ointments, home remedies, and prevention techniques can all be used to treat and prevent cold sores. It is important to understand the pros and cons of each treatment in order to choose the best option for your particular needs.
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