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Hypoallergenic Formula Comparison - September 2025
| 1 Best Choice  9.6Exceptional | 2  9.5Excellent | 3  9.4Excellent | 4 Best Value  9.3Excellent | 5  9.2Excellent | 6  9.1Excellent | 7  8.9Very Good |
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ModelEnfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 27.8 Oz Can | Model Similac Alimentum with 2'-FL HMO Hypoallergenic Infant Formula, for Food Allergies and Colic Due to Protein Sensitivity, Ready-to-Feed Baby Formula, 8-fl-oz Bottle, Pack of 24 | Model Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Concentrated Liquid, 8 Fl Oz, 24 Bottles | Model Enfamil Nutramigen Baby Formula, Hypoallergenic and Lactose Free Formula with Enflora LGG, Fast Relief from Severe Crying and Colic, Powder Can, 19.8 Oz (Pack of 1) | Model Similac Alimentum With 2'-FL HMO Hypoallergenic Infant Formula, for Food Allergies and Colic Due to Protein Sensitivity, Baby Formula Powder, 12.1-oz Can, Pack of 6 | Model Pepticate Baby Formula, Hypoallergenic Powdered Infant Formula for Cow Milk Allergy, with Omega 3 DHA, ARA, Iron & Prebiotics, 13.2oz | Model EleCare Hypoallergenic Amino Acid-Based Infant Formula, Complete Nutrition for Food Allergies and GI Conditions, Amino Acid-Based Baby Formula Powder, 14.1-oz Can |
BrandEnfamil | Brand Similac | Brand Nutramigen | Brand Nutramigen | Brand Similac | Brand NUTRICIA PEPTICATE | Brand EleCare |
Reviews | Reviews  | Reviews | Reviews | Reviews | Reviews | Reviews  |
Tech Specs | ||||||
product dimensions5.19 x 5.19 x 6.5 inches 1.74 Pounds | product dimensions 16.88 x 11.13 x 3.63 inches 10.53 ounces | product dimensions - | product dimensions 5.19 x 5.19 x 5 inches 1.24 Pounds | product dimensions - | product dimensions - | product dimensions 4.06 x 4.06 x 4.74 inches 14.1 ounces |
package dimensions- | package dimensions - | package dimensions 15 x 9.96 x 5.75 inches 15.7 Pounds | package dimensions - | package dimensions 12.87 x 8.54 x 4.96 inches 6.22 Pounds | package dimensions 5 x 4.06 x 4.02 inches 1 Pounds | package dimensions - |
Available On  | Available On | Available On | Available On  | Available On | Available On | Available On |
Our Top 3 Picks
Here are the top 3 recommended products with more information to help you find the right product for you
9.6
1EnfamilEnfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 27.8 Oz Can
Why we love it
Clinically proven relief for colic due to cow's milk allergy.
Fast relief within 48 hours for a happier baby.
Supports brain development with omega-3 DHA, ARA, and choline.
Main highlights- TRUSTED BY PEDIATRICIANS: Nutramigen is the #1 Trusted Hypoallergenic Formula Brand By Pediatricians
- SUPERSTAR LGG PROBIOTIC: The most extensively studied probiotic for allergy management that helps support your little one’s digestive health.
- SUBSCRIBE and SAVE: Choose Subscribe and Save for additional savings and convenience
- SNAP ELIGIBLE: Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits
- NOURISHING BRAIN DEVELOPMENT: Nutramigen, a gentle, lactose-free formula, has omega-3 DHA, ARA, and choline to support your baby's developing brain and eyes
- LACTOSE-FREE: suitable for babies with lactose intolerance
- IMMUNE SUPPORT: Help your baby's immune system adapt to standard milk formula
- HYPOALLERGENIC: made with extensively hydrolyzed proteins that are less likely to trigger an allergic response
- HELPS EASE YOUR LITTLE ONE’S COLIC: Delivers clinically proven relief when managing colic due to cow’s milk allergy for a happier, better-rested baby and mom
- GENTLE, FAST RELIEF: As early as the first feeding, Nutramigen starts to reduce excessive crying in less than 24 hours * – a soothing solution for your little one
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9.5
2Similac
Similac Alimentum with 2'-FL HMO Hypoallergenic Infant Formula, for Food Allergies and Colic Due to Protein Sensitivity, Ready-to-Feed Baby Formula, 8-fl-oz Bottle, Pack of 24
Why we love it
Reduces colic symptoms within 24 hours.
Hypoallergenic for sensitive babies.
Supports immune health with 2-FL HMO.
Main highlights- WITH AN IMMUNE-NOURISHING INGREDIENT: First and only hypoallergenic formula with 2'-FL HMO, an immune-nourishing ingredient
- START FEELING BETTER TODAY: Similac Alimentum starts reducing colic symptoms due to protein sensitivity within 24 hours in most infants
- SIMILAC IS THE #1 INFANT FORMULA BRAND FED IN HOSPITALS
- HYPOALLERGENIC: Our formula contains a milk protein that is broken down into tiny pieces to virtually eliminate allergic reactions in most babies who are allergic to cow’s milk protein
- GET MORE REWARDS POINTS: Scan the MySimilac QR code on select products to earn points toward a bonus offer
- EBT ELIGIBLE: Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits in select stores. The SNAP name is a service mark of the US Department of Agriculture. The USDA does not endorse any goods, services, or enterprises
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9.4
3Nutramigen
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Concentrated Liquid, 8 Fl Oz, 24 Bottles
Why we love it
Clinically proven relief for colic.
Fast relief within 48 hours.
Includes LGG probiotic.
Main highlights- TRUSTED BY PEDIATRICIANS : Nutramigen is the 1 Trusted Hypoallergenic Formula Brand By Pediatricians
- SUBSCRIBE and SAVE: Choose Subscribe and Save for additional savings and convenience
- SNAP ELIGIBLE: Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits
- READY-TO-FEED AT ANY TIME: Convivence with complete nutrition for your baby
- NOURISHING BRAIN DEVELOPMENT: Nutramigen, a gentle, lactose-free formula, has omega-3 DHA, ARA, and choline to support your baby's growing brain
- IMMUNITY SUPPORT: Help your baby's immune system adapt to standard milk formula
- HELPS EASE YOUR LITTLE ONE’S COLIC: Delivers clinically proven relief when managing colic due to cow’s milk allergy for a happier, better-rested baby and mom
- GENTLE, FAST RELIEF: As early as the first feeding, many babies experience improvement within just 48 hours – a comforting solution for your little one
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