Advertising Disclosure
Mthfr Vitamins Comparison - September 2025
| 1 Best Choice  9.8Exceptional | 2 Best Value  9.5Excellent | 3  9.4Excellent | 4  9.3Excellent | 5  9.2Excellent | 6  9.0Excellent | 7  8.8Very Good |
| View DealOn Amazon | View DealOn Amazon | View DealOn Amazon | View DealOn Amazon | View DealOn Amazon | View DealOn Amazon | View DealOn Amazon |
ModelMethyl Multi Without Iron Methylated Multivitamin for Men & Women, 120-Day Supply | Methyl B12 & Methylfolate (5-MTHF) for MTHFR Support | Pharma Grade Multivitamin & Multimineral For Health, 240 Caps | Model L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings) | Model THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg | Model Igennus Super B-Complex Methylated B Vitamins, All Day Nutrient Delivery, Clean Label, MTHFR Supplement with Methylfolate & B12 Methylcobalamin, Vegan, Lab Verified, 60 Small Tablets | Model Physician Designed MTHFR Daily Multivitamin | Methylated Multivitamin for Men & Women | for Energy, Mood, & Heart | Vitamin B-Complex | 120 Capsules | Model Igennus Methylated Kids Multivitamin Gummy, MTHFR, No Artificial Sweeteners or Flavors, Sugar Free, Age 4+, 90 Natural Berry Flavor Gummies from Fruit Powder, Non-GMO, Halal, Clean Label | Model Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy (1oz) |
BrandPure Therapro Rx | Brand Triquetra Health | Brand THORNE | Brand Igennus Healthcare Nutrition | Brand PD VARS | Brand Igennus Healthcare Nutrition | Brand Triquetra Health |
Reviews | Reviews  | Reviews | Reviews | Reviews | Reviews | Reviews  |
Features | ||||||
Simple to consume 9.4 | Simple to consume  9.8 | Simple to consume 9.9 | Simple to consume 9.8 | Simple to consume 9.9 | Simple to consume 9.3 | Simple to consume 9.1 |
Worth the money 9.6 | Worth the money 9.8 | Worth the money 9.4 | Worth the money 9.6 | Worth the money 9.1 | Worth the money 9.1 | Worth the money 8.9 |
Absorbency 9.6 | Absorbency 9.8 | Absorbency 9.6 | Absorbency 9.4 | Absorbency 9.1 | Absorbency 8.9 | Absorbency 8.6 |
Quality of ingredients 9.9 | Quality of ingredients 9.8 | Quality of ingredients 9.6 | Quality of ingredients 9.8 | Quality of ingredients 7.7 | Quality of ingredients 7.0 | Quality of ingredients 7.0 |
Flavor 9.4 | Flavor 9.8 | Flavor 9.6 | Flavor 8.9 | Flavor 9.1 | Flavor 8.1 | Flavor 7.9 |
Tech Specs | ||||||
product dimensions3 x 3 x 5 inches 7.2 ounces | product dimensions - | product dimensions - | product dimensions 1.85 x 1.85 x 3.43 inches 0.67 ounces | product dimensions 3.25 x 3 x 3 inches 1.59 ounces | product dimensions 2.76 x 2.76 x 4.72 inches 6.74 ounces | product dimensions 1.63 x 2.63 x 4.25 inches 3.21 ounces |
Review | Review - | Review | Review - | Review - | Review - | Review - |
Available On | Available On | Available On   | Available On | Available On | Available On | Available On |
Our Top 3 Picks
Here are the top 3 recommended products with more information to help you find the right product for you
9.8
1Pure Therapro RxMethyl Multi Without Iron Methylated Multivitamin for Men & Women, 120-Day Supply | Methyl B12 & Methylfolate (5-MTHF) for MTHFR Support | Pharma Grade Multivitamin & Multimineral For Health, 240 Caps
9.9 quality of ingredients9.6 worth the money9.6 AbsorbencyWhy we love it
Vegan-friendly and hypoallergenic formula.
Supports energy and cognitive function.
No artificial ingredients or fillers.
-
9.5
2Triquetra Health26% Off
L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)
9.8 simple to consume9.8 worth the money9.8 AbsorbencyWhy we love it
Clinically validated dosage of active folate.
Supports mood, energy, and heart health.
Positive customer feedback on mental clarity.
-
9.4
3THORNE
THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg
9.9 simple to consume9.6 Absorbency9.6 quality of ingredientsWhy we love it
Enhances folate absorption effectively.
Improves focus and mood noticeably.
Trusted by professionals and athletes.
Our ranking system
At BestChoice.com, our team curates a selection of top products from a vast array available online, using a sophisticated ranking system based on carefully defined criteria.While traditional hands-on testing has its merits, our use of AI technology offers distinct advantages. AI allows us to process and analyze vast amounts of data from multiple sources, providing a comprehensive view that goes beyond what manual testing can achieve. This approach enables us to deliver insights that are aligned with current trends and consumer preferences, ensuring our reviews are both relevant and up-to-date.
Features
Our AI-driven analysis examines key attributes, capabilities, and other critical factors tailored to each product category. This method allows us to assess effectiveness from various perspectives, ensuring a well-rounded evaluation.
Consumer Reviews
We aggregate and evaluate consumer feedback from across the internet, giving weight to ratings and reviews that reflect the most reliable insights. AI enhances this process by filtering and prioritizing data, offering a balanced view without the need for direct personal endorsements.
Popularity
Our system also considers the popularity of products, analyzing factors such as market presence, reputation, and user satisfaction. By leveraging AI, we capture a comprehensive picture of a product's standing in the market, which may not always be evident through traditional testing.
Value for money
AI allows us to compare products based on attributes like price, specifications, and user feedback, helping to determine their value for money. This data-driven approach offers an efficient and reliable way to assess how products stack up against one another in terms of cost-effectiveness.
